Question 1

How can a cancer cell be made to produce its own drug?

Accepted Answer

_The aim is a therapy produced by the tumor, against the tumor, in the tumor, so potent drugs stay local._

> We created the first genetic switches made out of DNA that only turn on in cancer cells. You inject them and they go everywhere, but they only flip on inside a cancer cell, like a light switch. We only get into about 1% of the cancer cells, so the cell produces a message, a smoke signal, that brings the immune system to attack the rest, like a domino chain reaction. The hard part is keeping all of it inside the tumor so you avoid off-target effects.